Kamis, 02 Oktober 2014

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Hubungi sekarang juga - Kami mengerjakan tugas kuliah kedokteran , makalah, paper, proposal skripsi, tugas akhir, dijamin orisinil dan otentik.  081 2946 35021

Jurnal yang sering digunakan untuk penelitian kedokteran:
             Cancer
             Nutrition & Cancer
             Journal of Clinical Oncology
             Journal of the National Cancer Institute
             Cancer Research
             Integrative Cancer Therapies
             American Journal of Clinical Nutrition
             Alternative Medicine Review
             International Journal of Cancer
             Clinical Pearls
             Anticancer Research
             Townsend Letter for Doctors & Their Patients

WEB RESOURCES
             www.oncanp.org
             www.aicr.org
             www.lifeovercancer.com
             www.cancerfacts.com
             www.nci.nih.gov
             www.cancernet.nci.nih.gov/clinpdq
             www.cancer.org      American Cancer Society  1-800-ACS-2345
             www.cdc.gov.org/cancer
             www.bccancer.bc.ca
             www.y-me.org
             www.asco.org
             www.Medscape.com  - oncology database
             www.inspirehealth.ca
             www.denvernaturopathic.com
             www.camresearch.net
             www.ncbi.nlm.nih.gov/PubMed/ 
             www.oncologystat.com 
             www.epec.net
             www.lifeovercancer.com

Topic penelitian yang sedang menarik yang dapat anda gunakan untuk diteliti:



Androgen Receptor-Dependent and -Independent Mechanisms Mediate Ganoderma lucidum Activities in LNCaP Prostate Cancer Cells, Zaidman, Wasser, Nevo & Mahajna, Int. J. Oncol. 2007; 31 (4): 959-967.

Effects of Water-soluble Ganoderma lucidum Polysaccharides on the Immune Functions of Patients with Advanced Lung Cancer, Gao, Tang, Dai, et al., J. Med. Food 2005; 8 (2): 159-168.

Effects of Ganopoly (A Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-stage Cancer Patients, Gao, Zhou, Jiang, et al., Immunol. Invest. 2003; 32 (3): 201-215.

Combined Effect of Green Tea and Ganoderma lucidum on Invasive Behaviour of Breast Cancer Cells, Thyagarajan, Zhu & Sliva, Int. J. Oncol. 2007; 30 (4): 963-969.

Telomerase-associated Apoptotic Events by Mushroom Ganoderma lucidum on Pre-malignant Human Urothelial Cells, Yuen, Gohel & Au, Nutr. Cancer 2008; 60 (1): 109-119.

Dietary Intakes of Mushrooms and Green Tea Combine to Reduce the Risk of Breast Cancer in Chinese Women, Zhng, Huang, Xie & Holman, Int. J. Cancer  2009; 1246: 1404-1408.

Ganoderma lucidum (Reishi) in Cancer Treatment, Sliva, Integr. Cancer Ther. 2003; 2 (4): 358-364.

The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment,  Kidd, Altern. Med. Rev. 2000; 5(1): 4-27.
Anticancer Effects of Ganoderma lucidum: A Review of Scientific Evidence, Yuen & Gohel Nutr. Cancer 2005; 53 (1): 11-17
 Natural Killer Cell Activity and Quality of Life Were Improved by Consumption of a Mushroom Extract, Agaricus blazei Murill Kyowa, in Gynecological Cancer Patients Undergoing Chemotherapy, Ahn, Kim, Chae, et al., Int. J. Gynecol. Cancer 2004; 14 (4): 589-594.
Secretion of TNF-alpha, IL-8 and Nitric Oxide by Macrophages Activated with Agaricus blazei Murill Fractions in vitro, Sorimachi, Akimoto, Ikehara, et al., Cell Struct. Funct. 2001; 26 (2): 103-108.
Characterization and Immuno-modulating Activities of Polysaccharide from Lentinus edodes, Zheng, Jie, Hanchuan & Moucheng, Int. Immunopharmacol. 2005; 5 (5): 811-820.
Effects of Ganopoly (a Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-stage Cancer Patients, Gao, Zhou, Jiang, et al., Immunol. Invest. 2003; 32 (3): 201-215.
Protective Effects of Ganoderma lucidum Polysaccharides Peptide on Injury of Macrophages Induced by Reactive Oxygen Species, You & Lin, Acta Pharmacol. Sin. 2002; 23 (9): 787-791.
The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment, Kidd, Altern. Med. Rev. 2000; 5 (1): 4-27.
Anticancer Effects and Mechanisms of Polysaccharide-K (PSK):  Implications of Cancer Immunotherapy, Fisher & Yang,  Anticancer Res. 2002; 22 (3): 1737-1754.
A Review of Research on the Protein-bound Polysaccharide (Polysaccharopeptide, PSP) from the Mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae), Ng, Gen. Pharmacol. 1998; 30 (1): 1-4. 
Augmentation of Various Immune Reactivities of Tumor-bearing Hosts with an Extract of Cordyceps sinensis,Yamaguchi, Yoshida, Ren et al., Biotherapy 1990; 2 (3): 199-205.
Effect of Cordyceps sinensis on the Th1/Th2 Cytokines in Patients with Condylomata Acuminata, Gao, Wuu & He,  Zhong Yao Cai 2000; 23 (7): 402-404.
The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment, Kidd, Altern. Med. Rev. 2000; 5 (1): 4-27.
Supplements for Immune Enhancement in Hematological Malignancies, Sze & Chan, Hematology 2009; 313-319.
Ganoderma lucidum Inhibits Proliferation of Human Breast Cancer Cells by Down-Regulation of Estrogen Receptor and Nf-kappaB Signalling, Jiang, Slivova & Sliva, Int. J. Oncol. 2006; 29: 695-703.

Ganoderic Acids Suppress Growth  and Invasive Behaviour of Breast Cancer Cells by Modulating AP-1 and NF-kappaB Signalling, Jiang, Grieb, Thyagarajan & Sliva, Int. J. Mol. Med. 2008; 21: 577-584.

Ganoderma lucidum Inhibits Proliferation and Induces Apoptosis in Human Prostate cells PC-3, Jiang, Slivova, Valachovicova, et al., Int. J. Oncol. 2004; 24: 1093-1099.


OMEGA 3 OILS
Modulation of Angiogenesis by Omega-3 Polyunsaturated Fatty Acids is Mediated by Cyclooxygenases, Szymczak, Murray & Petrovic,  Blood 2008; 111 (7): 3514-3521.

N-3 Fatty Acids, Cancer and Cachexia: A Systematic Review of the Literature, Colomer, Moreno-Nogufeira, Garcia-Luna, et al., Br. J. Nutr. 2007; 975: 823-831.

Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk. Fradet , Cheng, Casey &Witte,  Clin Cancer Res. 2009; 15 (7): 2559-2566.

Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination with Omega-3 Fatty Acids, Swamy, Citineni, et al, Nutr. Cancer  2008; 60 Suppl. 1: 81-89.

Omega 3 Fatty Acids: Biological Activity and Effects on Human Health, La Guardia, Giammanco, Di Majo, et al., Panminerva Med. 2005; 47 (4): 245-257.

Effect of Eicosapentaenoic Acid, Protein and Amino Acids on Protein Synthesis and Degradation in Skeletal Muscle of Cachectic Mice, Smith, Greenberg & Tisdale,  Br. J. Cancer 2004; 91 (2): 408-412.

Role of Omega-3 Fatty Acid Supplementation in Inflammation and Malignancy, Jho, Cole, Lee & Espat, Integr. Cancer Ther. 2004; (2): 98-111.

Cytotoxic Drugs Efficacy Correlates with Adipose Tissue Docosahexaenoic Acid Level in Locally Advanced Breast Carcinoma, Bougnoux, Germain, Chajes, et al.,  Br. J. Cancer 1999; 79 (11-12): 1765-1769.

Complementary Actions of Docosahexaenoic Acid and Genistein on COX-2, PGE2 and Invasiveness in MDA-MB-231 Breast Cancer Cells, Horia E, Watkins BA.   Carcinogenesis 2007; 28 (4): 809-815.

n-3 PUFAs Modulate T-cell Activation via Protein Kinase C-alpha and -epsilon and the NF-kappaB Signaling Pathway, Denys , Hichami & Khan,  J. Lipid Res. 2005; 46 (4): 752-758.

 n-3 Fatty Acids, Inflammation, and Immunity: Relevance to Post-surgical and Critically Ill Patients, Calder, Lipids 2004; 39 (12): 1147-1161.

Impact of Post-operative Omega-3 Fatty Acid-supplemented Parenteral Nutrition on Clinical Outcomes and Immuno-modulations in Colorectal Cancer Patients, Liang, Wang, Ye, et al., World J. Gastroenterol. 2008; 14 (15): 2434-2439.

High Omega-3 Fat Intake Improves Insulin Sensitivity and Reduces CRP and IL6, But Does Not Affect Other Endocrine Axes in Healthy Older Adults, Tsitouras, Gucciardo, Salbe, et al., Horm. Metab. Res. 2008; 40 (3): 199-205.

Dietary Omega-3 Fatty Acids, Cyclo-oxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk, Fradet, Cheng, Casey & Witte, Clin, Cancer Res. 2009; 15 (7): 2559-2566.

The Potential for Treatment with Dietary Long-chain Polyunsaturated n-3 Fatty Acids During Chemotherapy, Biondo, Brindley, Sawyer & Field, J. Nutr. Biochem. 2008; 1912: 787-796.

Chemoprotective and Renal Protective Effects for Docosahexaenoic Acid (DHA): Implications of CRP and Lipid Peroxides, Elmesery, et al., Cell Div. 2009; 4 (1): 6.

Omega-3 Fatty Acids Can Improve Radioresponse Modifying Tumor Interstitial Pressure, Blood Rheology and Membrane Peroxidability, Baronzio, Freitas, Griffini et al., Anticancer Res.  1994; 14 (3A): 1145-1154

Neuroblastoma Cell Death in Response to Docosahexaenoic acid: Sensitization to Chemotherapy and Arsenic-induced Oxidative Stress, Lindskog, Gleissman, Ponthan et al.,  Int. J. Cancer 2006; 118 (10): 2584-2593.

Differential Sensitization of Cancer Cells to Doxorubicin by DHA: A Role for Lipoperoxidation, Maheo, Vibet, Steghens et al., Free Radic. Biol. Med. 2005; 39 (6): 742-751.

Sensitization by Docosahexaenoic Acid (DHA) of Breast Cancer Cells to Anthracyclines Through Loss of Glutathione Peroxidase (GPx1) Response, Vibet, Goupille, Bougnoux, et al.,  Free Radic. Biol. Med. 2008; 44 (7): 1483-1491.

Phase II Study of High-dose Fish Oil Capsules for Patients with Cancer-Related Cachexia, Burns, Halabi, Clamon, et al., Cancer 2004; 101: 370-378.

The Effect of Dietary Omega-3 Polyunsaturated Fatty Acids on T-lymphocyte Subsets of Patients with Solid Tumors, Gogos, Ginopoulos, Zoumbos, et al., Cancer Detect. & Prev. 1995; 19 (5): 415-417.

Enteral (Oral or Tube Administration) Nutritional Support and Eicosapentaenoic Acid in Patients with Cancer: A Systematic Review, Elia, Van Bokhorst-de van der Schueren, Garvey, et al., Int. J. Oncol. 2006; 28 (1): 5-23.

Effect of a Protein and Energy Dense N-3 Fatty Acid Enriched Oral Supplement on Loss of Weight and Lean Tissue in Cancer Cachexia: A Randomised Double Blind Trial, Fearon, Von Meyenfeldt, Moses, et al., Gut 2003; 52 (10): 1479-1486.

Modulation of Inflammation and Cytokine Production by Dietary (n-3) Fatty Acids, Blok, Katan & van der Meer,  J. Nutr. 1996; 126 (6): 1515-1533.

Effect of Dietary Fish Oil on Development and Selected Functions of Murine Inflammatory Macrophages, Hubbard, Somers & Eriskson, J. Leukoc. Biol. 1991; 49: 592.

Antitumor Activity of Fish Oils Against Human Lung Cancer is Associated with Altered Formation of PGE2 and PGE3 and Regulation of Akt Phosphorylation, Yang, Chan, Cartwright, et al., 5th AACR Int. Conf. Frontiers Cancer Prev. Res. 2006.
Dietary Omega-3 Polyunsaturated Fatty Acids Plus Vitamin E Restore Immunodeficiency and Prolong Survival for Severely Ill Patients with Generalized Malignancy: A Randomized Control Trial, Gogos, Ginopoulos, Salsa, et al., Cancer 1998; 82 (2): 395-402.
Improving Outcome of Chemotherapy of Metastatic Breast Cancer by Docosahexaenoic Acid: A Phase II Trial, Bougnoux, Hajjaji, Ferrasson, et al., Br. J. Cancer 2009; 101 (12): 1978–1985.

Dietary Omega-3 Fatty Acids, Cyclooxygenase-2, Genetic Variation and Aggressive Prostate Cancer Risk, Fradet, Cheng, Casey & Witte, Clin. Cancer Res. 2009; 157: 2559-2566.
Dietary n-3 Polyunsaturated Fatty Acids Enhance Metastatic Dissemination of Murine T Lymphoma Cells, Mannini, Kerstin, Calorini, et al., Br. J. Nutr. 2009; 102 (7): 958-961.
Marine Fatty Acid Intake Is Associated with Breast Cancer Prognosis, Patterson, Pierce, et al, J. Nutr, 2010 Dec 22; [Epub ahead of print].

Mechanism of Attenuation of Skeletal Muscle Protein Catabolism in Cancer Cachexia by Eicosapentaenoic Acid, Whitehouse, Smith, Drake & Tisdale, Cancer Res.  2001; 61 (9): 3604-3609.

Fish Oil Prevents Breast Cancer Cell Metastasis to Bone, Mandal, Ghosh-Choudhury, Yoneda, et al., Biochem. Biophys. Res. Comm. 2010; 402: 602–607.

Phase I Clinical Study of Fish Oil Fatty Acid Capsules for Patients with Cancer Cachexia: Cancer and Leukemia Group B Study 9473, Burns, Halabi, Clamon, et. al., Clin. Cancer Res. 1999; 5: 3842–3947.



PHYTOESTROGENS  & SOY
Phytoestrogens and Antioxidants – Bits of Experimental Evidence, Mariani, Medscape General Medicine 01/24/2005

Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer, Piersen, Integr. Cancer Ther., 2003; 2 (2): 120-138. 

Dietary Phytoestrogen Intake – Lignans, Isoflavones – and Breast Cancer Risk (Canada), Cotterchio, Boucher, Kreiger, et al.,  Cancer Causes & Control 2008; 193: 259-272.

Flaxseed Oil Reduces the Growth of Human Breast Tumors (MCF-7) at High Levels of Circulating Estrogen,
Truan, Chen & Thompson,  Mol. Nutr. Food Res. 2010; 54: 1–8.

Flaxseed Oil–Trastuzumab Interaction in Breast Cancer, Mason, Chen & Thompson, Food Chem Tox. 2010;
doi:10.1016/j.fct.2010.05.052

Phytoestrogen Content of Foods Consumed in Canada, Including Isoflavones, Lignans, and Coumestan, Thompson, Boucher, Liu, et al., Nutr. Cancer, 2006; 54 (2): 184-201.

Dietary Lignan Intakes in Relation to Survival Among Women with Breast Cancer: The Western New York Exposures and Breast Cancer (WEB) Study, McCann, Thmpson, Nie, et al., Breast Cancer Res. Treat.  2010; 122 (1): 229-235.

Inhibitory Effect of Isoflavones on Prostate Cancer Cells and PTEN Gene, Cao, Jin & Zhou, Biomed. Environ. Sci. 2006; 19 (1): 35-41.

Induction of Apoptosis in Low to Moderate Grade Human Prostate Carcinoma by Red Clover-Derived Dietary Isoflavones, Jarred, Keikha, Dowling, et al., Cancer Epidemiol. Biomarkers Prev.  2002; 11 (12): 1689-1696.

Multi-targeted Therapy of Cancer by Genistein, Banerjee, Li, Wang & Sarkar, Cancer Lett. 2008; 269 (2): 226-242.

Xenoestrogens Modulate Vascular Endothelial Growth Factor Secretion in Breast Cancer Cells Through an Estrogen Receptor-dependent Mechanism, Buteau-Lozano, Velasco, Cristofari, et al., J. Endocrinol. 2008; 196 (2): 399-412.

Potentiation of the Effect of Erlotinib by Genistein in Pancreatic Cancer: The Role of Akt and Nuclear Factor-kappaB,  E-Rayes, Ali, Ali, et al., Cancer Res. 2006; 66 (21): 10553-10559.

Effect of Soybean on Breast Cancer According to Receptor Status: A Case-control Study in Japan, Suzuki, Matsuo, Tsunoda, et al., Int. J. Cancer 2008; 123 (7): 1674-1680.

Soy Isoflavones, Estrogen Therapy, and Breast Cancer Risk: Analysis and Commentary, Messina & Wood,  Nutr. J. 2008; 7: 17.

Genestein Inhibits p38 Map Kinase Activation, Matrix Metalloproteinase Type 2, and Cell Invasion in Human Prostate Epithelial Cells, Huang, Chen, Xu, et al., Cancer Res. 2005; 65 (8): 3470-3478.

Genestein Induces Cell Growth Inhibition in Prostate Cancer Through the Suppression of Telomerase Activity, Ouchi, Ishiguro, Ikeda, et al., Int. J. Urol. 2005; 12 (1): 73-80.

Genestein Inhibits Vitamin D Hydroxylases CYP24 and CYP27B1 Expression in Prostate Cells, Farhan, et al., J. Steroid Biochem. Mol. Biol. 2003; 84 (4): 423-429.

Genestein Potentiates the Growth Inhibitory Effects of 1,25-dihydroxyvitamin D(3) in DU145 Human Prostate Cancer Cells:  Role of the Direct Inhibition of CYP24 Enzyme Activity, Swami, et al., Mol. Cell Endocrinol. 2005;   

Soy-derived Isoflavones Inhibit the Growth of Adult T-cell Leukemia Cells in vitro and in vivo, Yamasaki, Fujita, Ishiyama, et al., Cancer Sci. 2007; 98 (11): 1740-1746.

Implications of Phytoestrogen Intake for Breast Cancer, Duffy, Perez & Partridge, CA Cancer J. Clin. 2007; 57 (5): 260-277.

Addressing the Soy and Breast Cancer Relationship: Review, Commentary, and Workshop Proceedings, Messina M, McCaskill-Stevens W, Lampe JW.  J. Natl. Cancer Inst. 2006; 98 (18): 1275-1284.

Point-Counterpoint: Soy Intake for Breast Cancer Patients, Block, Constantinou, Hilakivi-Clarke et al., Integr. Cancer Ther. 2002; 1 (1): 90-100.

Various Doses of Soy Isoflavones Do Not Modify Mammographic Density in Postmenpausal Women, Masarinec, Verheus, Steinberg et al., J. Nutr. 2009; 139 (5): 981-986.

Dietary Intake of Isoflavones and Breast Cancer Risk by Estrogen and Progesterone Receptor Status, Zhang, Yang & Holman, Breast Cancer Res. Treat.  2009;  Epub  Feb. 28, 2009; DOI 10.1007/s10549-009-0354-9.

Dietary Soy Intake and Breast Cancer Risk, Enderlin, Coleman, Stewart & Hakkak, Oncol. Nurs. Forum 2009; 36 (5): 531-539.

Effects of Diverse Dietary Phytoestrogens on Cell Growth, Cell Cycle and Apoptosis in Estrogen-Receptor Positive Breast Cancer, Sakamoto, Horiguchi, Oguma & Kayama, J. Nutr. Biochem. 2009; Oct 2. [Epub ahead of print] PMID: 19800779.

Soy Food Intake and Breast Cancer Survival, Shu, Zheng, Cai et al., J. Amer. Med. Assoc. 2009; 302 (22): 2437-2443.
Soy Isoflavones in Conjunction with Radiation Therapy in Patients with Prostate Cancer. Ahmad, Forman, Sarkar, et al. Nutr. Cancer 2010; 627: 996-1000.
Effects of a Flaxseed Mixture and Plant Oils Rich in Alpha-Linolenic Acid on the Adenoma Formation in Multiple Intestinal Neoplasia (Min) Mice, Oikarinen, Pajari, Salminen et al., Br. J. Nutr. 2005; 94 (4): 510-518.

Flaxseed and its Lignans Inhibit Estradiol-induced Growth, Angiogenesis, and Secretion of Vascular Endothelial Growth Factor in Human Breast Cancer Xenografts in vivo, Bergman, Jungeström, Thompson & Dabrosin, Clin. Cancer Res. 2007; 13 (3): 1061-1067.

Dietary Lignan Intakes in Relation to Survival Among Women with Breast Cancer: The Western New York Exposures and Breast Cancer (WEB) Study, McCann, Thompson, Nie, et al., Breast Cancer Res. Treat. 2010; 122 (1): 229-235.

POMEGRANATE & ELLAGIC ACID
Pomegranate Extract Inhibits Androgen-independent Prostate Cancer Growth Through a Nuclear Factor Kappa-B dependent Mechanism, Rettig, et al., Mol. Cancer Ther. 2008; 7 (9): 2662-2671.

In vitro Anti-proliferative, Apoptotic and Antioxidant Activities of Punicalagin, Ellagic Acid and a Total Pomegranate Tannin Extract are Enhanced in Combination with other Polyphenols as Found in Pomegranate Juice, Seeram, Adams, Henning, et al., J. Nutr. Biochem. 2005; 16 (6): 360-367.

Pomegranate Polyphenols  Down-regulate Expression of Androgen-synthesizing Genes in Human Prostate Cancer Cells Over-expressing the Androgen Receptor, Young, Hong, Seeram & Heber, J. Nutr. Biochem. 2008; 19 (12): 848-855.

Ellagic Acid Induces Apoptosis Through Inhibition of Nuclear Factor Kappa B in Pancreatic Cancer Cells, Edderkaoui, Odinokova, Ohno, et al., World J. Gastroenterol. 2008; 14 (23): 3672-3680.

Combined Inhibition of PDGF and VEGF Receptors by Ellagic Acid, a Dietary-derived Phenolic Compound, Labrecque, Lamy, Chapus, et al.,Carcinogenesis 2005; 26 (4): 821-826.

 In vitro Anti-proliferative Activities of Ellagic Acid, Losso, Bansode, Trappey, et al.,  J. Nutr. Biochem. 2004;15 (11): 672-678.

Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (HRPC) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate, Falsaperla, Morgia, Tartarone, et al., Eur. Urol. 2005; 47 (4): 449-454.

 Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen Following Surgery or Radiation for Prostate Cancer, Pantuck, Leppert, Zomorodian, et al., Clin. Cancer Res. 2006; 12 (13): 4018-4026.

Berry Phytochemicals, Genomic Stability and Cancer: Evidence for Chemoprotection at Several Stages in the Carcinogenic Process, Duthie, Mol. Nutr. Food Res. 2007; 51 (6): 665-674.



PREVENTION
Molecular Targets of Phytochemicals for Cancer Prevention, Lee, Bode & Dong, Rev. Cancer 2011; 11 (3): 211-218.

Prostate Cancer Prevention by Nutritional Means to Alleviate Metabolic Syndrome, Barnard, Amer. J. Clin. Nutr. 2007; 863, s. 889-893.

Cancer Prevention – the Easy Choices, McKinney, Alive - Canadian Journal of Health & Nutrition, April 2005; 270: 48-53.
Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-grade Prostate Intraepithelial Neoplasia, A Preliminary Report from a One-year Proof-of-Principle Study, Betuzzi, Brausi, Rizzi & Castagnetti, Cancer Res. 2006; 66 (2): 1234-1240.

Resveratrol: a Candidate Nutritional Substance for Prostate Cancer Prevention, Stewart, Artime & O’Brian,  J. Nutr. 2003; 133 (7 Suppl.): 2440S-2443S.

How to Prevent and Treat Cancer with Natural Medicine, Murray, Birdsall, Pizzorno & Reilly, Riverhead Books, 2002.

Antioxidant Vitamin and Mineral Supplementation May Help Prevent Prostate Cancer Meyer, et al., Int. J. Cancer, 2005; 116: 182-186.

Herbicides and Non-Hodgkins Lymphoma: New Evidence from a Study of Saskatchewan Farmers, Blair, J. Int. Cancer Inst. 1990; 85: 544-545.

Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes, Searles Nielsen, McKean-Cowdin, Federico, et al., Envir. Health Perspect. 118:144–149 (2010).

Glutathione Treatment of Hepatocellular Carcinoma, Dalhoff, et al., Liver 1992; 12: 341-343.

EcoCancers: Do Environmental Factors Underlie a Breast Cancer Epidemic?, Raloff, Sci. News 1993; 144: 10-13.

Paraben Esters: Review of Recent Studies of Endocrine Toxicity, Absorption, Esterase and Human Exposure, and Discussion of Potential Human Health Risks, Darbe & Harvey, J. Appl. Toxicol. 2008; 285: 561-578.

Coffee Consumption and the Risk of Oral, Pharngeal and Esophageal Cancers in Japan: The Miyagi Cohort Study, Naganuma, Kuriyama, Kakizaki, et al., Am. J. Epidemiol. 2008; 16812: 1425-1432.

Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-metabolizing Enzymes, and Colorectal Cancer Risk, Cotterchio, Boucher, Manno, et al., Cancer Epidemiol. Biomarkers & Prev. 2008; 1711: 3098-3107.


QUERCITIN
Suppression of Insulin-like Growth Factor Signalling Pathway and Collagen Expression in Keloid-derived Fibroblasts by Quercetin: Its Therapeutic Potential Use in the Treatment and/or Prevention of Keloids, Phan, See, Tran, et al., Br. J. Dermatol. 2003; 148 (3): 544-552.

Differential Responses of Skin Cancer Chemoprotective Agents Silibinin, Quercitin and Epigallocatechin 3-Gallate on Mitogenic Signalling and Cell Cycle Regulators in Human Epidermoid carcinoma A431 Cells, Bhatia, Agarwal & Agarwal,  Nutr. & Cancer.  2001; 39 (2); 292-299.

Role of Mitochondria in Quercitin-enhanced Chemotherapeutic Response in Human Non-Small Cell Lung Carcinoma H-520 Cells,  Kuhar, Sen & Singh,  Anticancer Res. 2006; 26 (2A): 1297-1303.

Inhibition of Lung Cancer Cell Growth by Quercitin Glucoronides via G2/M Arrest and Induction of Apoptosis, Yang, Hsia, Kuo, et al., Drug Metab. Dispos. 2006, 34 (2): 296-304.

Induction of Cell-cycle Arrest and Apoptosis in Human Breast cancer Cells by Quercitin, Choi, Kim, Lee, et al., Int. J. Oncol. 2001; 19 (4): 837-844.

Antioxidants and Cancer III – Quercitin, Lamson & Brignall, Alt. Med. Rev. 2000; Vol. 5 No. 6: 196-208.

Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines, Ramos & Aller, Biochem Pharmacol. 2008;75 (10):1912-1923.

Apple Phytochemicals and Their Health Benefits, Boyer & Liu, Nutr. J. 2004; 3 (5)

Enhanced Bioavailability of Tamoxifen after Oral Administration of Tamoxifen with Quercitin in Rats, Shin, Choi & Li, Int. J. Pharm. 2006; 313 (1-2): 144-149.

Inhibition of P-Glycoprotein by Flavonoid Derivatives (Quercitin and Morin) in Adriamycin-Resistant Human Myelogenous Leukemia (K562/ADM) Cells, Ohtani, Koyabu, Juichi, et al., Cancer Lett. 2002; 177 (1): 89-93.

Effects of Quercitin on the Cell Growth and the Intracellular Accumulation and Retention of Adriamycin, Asaum, Matsuzaki, Kawasak, et al., Anticancer Res. 200; 20 (4): 2477-2483.

Quercitin Potentiates the Effect of Adriamycin in a Multi-Drug-Resistant MCF-7 Human Breast Cancer Cell Line: P-Glycoprotein as a Possible Target, Scambia, Ranelletti, Panici, et al., Cancer Chemother. Pharmacol. 1994; 34 (6): 459-464.

Suppression of Multi-Drug Resistance Via Inhibition of Heat Shock Factor by Quercitin in MDR Cells, Kim, Yeo, Lim, et al., Exp. Mol. Med. 1998; 30 (2): 87-92.

Synergistic Antiproliferative Activity of Quercitin and Cisplatin on Ovarian Cancer Cell Growth, Scambia, Ranelletti, Benedetti, et al., Anticancer Drugs 1990; 1 (1): 45-48.

Drug Resistance Against Gemcitabine and Topotecan Mediated by Constituitive HSP-70 Over-expression in vitro: Implication of Quercitin as a Sensitiser in Chemotherapy, Sluitz, Karlseder, Temfer, et al., Br. J. Cancer 1996; 74 (2): 172-177.

Low-concentrations of Quercitin and Ellagic Acid Synergistically Influence Proliferation, Cytotoxicity and Apoptosis in MOLT-4 Human Leukemia Cells, Mertens-Talcott, Talcott & Percival, J. Nutr. 2003; 133 (8): 2669-2674.

Spontaneous mitochondrial membrane potential change during apoptotic induction by quercitin in K562 and K562/adr cells, Kothan, Dechsupa, Leger, et al., Can. J. Physiol. Pharmacol. 2004, 82 (12): 1084-1090.

Food-derived Polyphenols Inhibit Pancreatic Cancer Growth Through Mitochondrial Cytochrome C Release and Apoptosis, Suolinna, Buschbaum & Racker, Cancer Res. 1975; 35 (7): 1865-1872.

Quercitin Induces Necrosis and Apoptosis in SCC-9 Oral Cancer Cells, Haghiac & Walle, Nutr. Cancer 2005; 53 (2):220-231.

Selective Aromatase Inhibition for Patients with Androgen-independent Prostate Carcinoma, Smith, Kaufman, George, et al., Cancer  2002; 95 (9): 1864-1868.

Absorption and Disposition Kinetics of the Dietary Antioxidant Quercitin in Man, Hollman, vd Gaag, Mengelers, et al., Free Rad Biol Med  1996; 21 (5): 703-707.

Quercetin Potentiates the Effect of Adriamycin in a Multidrug-resistant MCF-7 Human Breast-Cancer Cell Line: P-glycoprotein as a Possible Target, Scambia, Ranelletti, Panici, et al.  Cancer Chemother.  Pharmacol.  1994; 34 (6): 459-464.

Flavonoids: a Class of Modulators with Bifunctional Interactions at Vicinal ATP- and Steroid-binding Sites on Mouse P-glycoprotein, Conseil,  Baubichon-Cortay, Dayan, et al., Proc. Nat. Acad. Sci. 1998; 95 (17): 9831-9836.

Absorption of Dietary Quercetin Glycosides and Quercetin in Healthy Ileostomy Volunteers, Hollman, de Vries, van Leeuwen, Mengelers,& Katan, (1995). Amer. J. Clin. Nutr. 1995; 62: 1276–1282.

The Synergistic Reversal Effect of Multidrug Resistance by Quercetin and Hyperthermia in Doxorubicin-Resistant Human Myelogenous Leukemia Cells, Shen, Zhang, Wu & Zhu, Int. J. Hyperthermia  2008 ;24 (2): 151-159.

Apoptosis of Murine Melanoma B16-BL6 Cells Induced by Quercetin Targeting Mitochondria, Inhibiting Expression of PKC-alpha and Translocating PKC-delta, Zhang, Chen, Xia & Xu,  Cancer Chemother. Pharmacol. 2005; 55 (3): 251-262.

Quercetin-Induced Ubiquination and Down-Regulation of Her2/neu, Jeong, An, Kwon, et al., J. Cell Biochem. 2008; 105: 585-595.


RADIATION
Timing is Everything in Combined Antiangiogenic / Radiation Therapy, Jain, Cancer Cell  2004; 6: 553-563.

Effects of Zinc Supplementation on Clinical Outcomes in Patients Receiving Radiotherapy for Head and Neck Cancers: a Double-blinded Randomized Study, Lin, Que, Lin, et al., Int. J. Radiat. Oncol. Biol. Phys. 2008; 702: 368-373.

Antioxidants and Radiation Therapy, J. Nutr.  Borek, 2004; 134: S3207-S-3209.

Effects of Rhubarb Extract on Radiation Induced Lung Toxicity Via Decreasing Transforming Growth Factor Beta-1 and Interleukin-6 in Lung Cancer Patients Treated with Radiotherapy, Yu, Liu, Cheng, et al., Lung Cancer 2008; 592: 219-226.

ARCON (accelerated radiotherapy with carbogen and nicotinamide): a Novel Biology-based Approach in Radiotherapy  Kanders, Bussink & van der Kogel, Lancet Oncol. 2002; 3 (12): 728-737.

Radiosensitization by Nicotinamide in vivo: A Greater Enhancement of Tumor Damage Compared to that of Normal Tissue, Horsman, Chaplin & Brown, Rad. Res. 1987; 109: 479-489.

Mechanism of Action of the Selective Tumor Radio-Sensitizer Nicotinamide, Horsman, Brown, et al,  Int. J. Rad. Onc. Biophys. 1988; 15: 685-690.

Nicotinamide and Other Benzamide Analogs as Agents for Overcoming Hypoxic Cell Radiation Resistance in Tumors. A Review, Horsman, Acta Oncol. 1995; 34 (5): 571-587.

Do Antioxidants Interfere with Radiation Therapy for Cancer?, Moss, Integr. Cancer Ther. 2007, 6 (3): 281-292.

Acute Adverse Effects of Radiation Therapy and Local Recurrence in Relation to Dietary and Plasma Beta Carotene and Alpha Tocopherol in Head and Neck Cancer Patients, Meyer, Bairati, Jobin, et al., Nutr. Cancer  2007; 59 (1): 29-35.

Dietary Counselling Benefits Patients Undergoing Radiotherapy, Ravasco. et al., J. Clin. Oncol. 2005; 23: 1348-1349, 1431-1438.

Effect of Concomitant Naturopathic Therapies on Clinical Tumor Response to External Beam Radiation Therapy for Prostate Cancer (Abstract), Birdsall, Alschuler, Martin, et al., Soc. Integr. Oncol.  Nov. 2006, Boston, Mass.

Effect of Complementary Alternative Medical (CAM) Therapy on Tumor Response in Prostate Cancer Patients Treated with Radiation Therapy, Cain, Flynn, Kelly, et al., J. Clin. Oncol. 2007; 25: 15585.

Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation, Saha & Choy, Prog Exp. Tumor Res. 2003; 37: 193-209.

Long-term Use of Cellular Phones and Brain Tumours: Increased Risk Associated with Use for >=
10 Years, Hardell, Carlberg, Soderqvist, et al., Occup. Envir. Med. 2007; 64 (9): 626-632.

Oral Vitamin A Therapy for a Patient with a Severely Symptomatic Post-Radiation Anal Ulceration, Levitsky, Hong, Jani & Ehrenpreis, Dis. Colon Rectum 2003; 46 (5): 679- 682.

Phase I Study of Concurrent Radiotherapy with TS-1 and Vitamin A (TAR Therapy) for Head and Neck Cancer, Nakashima, Kuramoti, Yamamoto, et al., Gan To Kagaku Ryoho  2005; 32 (6): 803-807.

Sensitization of Cervical Cancer Cell Lines to Low-dose Radiation by Retinoic Acid Does Not Require Functional p53, Tillmanns, Kamelle, Guruswamy, et al., Gynecol Oncol 2005; 97 (1): 142-150.

Supplemental Vitamin A Prevents the Acute Radiation-induced Defect in Wound Healing, Levenson, Gruber, Rettura, et al., Ann. Surg. 1984; 200 (4): 494-512.

Protective Effect of Vitamin A on Acute Radiation Injury in the Small Intestine, Beyzadeoğlu, Balkan, Demiriz, et al., Radiat. Med. 1997; 15 (1): 1-5.

A New Electromagnetic Exposure Metric: High Frequency Voltage Transients Associated with Increased Cancer Incidence in Teachers in a California School, Milham & Morgan, Am. J. Ind. Med. 2008; 51(8):579-586.

Arachidonic Acid Metabolites Mediate the Radiation-induced Increase in Glomerular Albumin Permeability, Sharma, McCarthy, Sharma, et al., Exp. Biol. Med. 2006; 231: 99-106.

Enhanced Radiosensitivity of Rat Autochthonous Mammary Tumors by Dietary Docosahexaenoic Acid, Colas, Paon, Denis, et al., Int. J. Cancer 2004; 109 (3): 449-454.

[Omega-3 Fatty Acid-containing Diet (Racol) Reduces Toxicity of Chemo-radiation Therapy for Patients with Esophageal Cancer], Minami, Miyata, Doki, et al., Gan To Kagaku Ryoho 2008; 35 (3): 437-440.

Aloe vera for Preventing Radiation-induced Skin Reactions: A Systematic Literature Review, Richardson, Smith, McIntyre, et al., Clin. Oncol (R. Coll. Radiol). 2005; 17 (6): 478-484.

Prevention of Chemotherapy and Radiation Toxicity with Glutamine, Savarese, Savy, Vahdat, et al., Cancer Treat. Rev. 2003; 29 (6): 501-513.

Successful and Sustained Treatment of Chronic Radiation Proctitis with Antioxidant Vitamins E and C,  Kennedy, Bruninga, Mutlu, et. al., Am. J.Gastroenterol. 2001; 96 (4): 1080-1084.

Protective effects of Berberine on Radiation-induced Lung Injury via Intercellular Adhesion Molecule-1 and Transforming Growth Factor beta-1 in Patients with Lung Cancer, Liu, Yu, Zhang, et al., Eur. J. Cancer 2008; 44 (16): 2425-2432.

D-alpha-tocopherol Succinate (Vitamin E) Enhances Radiation-induced Chromosomal Damage Levels in Human Cancer Cells, but Reduces it in Normal Cells, Kumar, Jha, Cole, et al., J. Amer. Coll Nutr. 2002; 21 (4): 339-343.

Can the Therapeutic Gain of Radiotherapy Be Increased by Concurrent Administration of Asian Botanicals?, Sagar, Integr. Cancer Ther. 2010; 9 (1): 5-13.   Dr. Lawenda’s response pp. 14-15.

Curcumin – a New Radiosensitizer of Squamous Cell Carcinoma Cells, Khafif, et al., Otolarngol. Head Neck Surg., 2005; 132: 317-321.

Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to ɤ-Radiation by Targeting
Nuclear Factor-B–Regulated Gene Products, Kunnumakkara1, Diagaradjane, Guha, et al., Clin.Cancer Res.  2008;14: 2128-2136.

The Chemopreventative Agent Curcumin is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased ROS production and Overactivation of the MAPK Pathway, Javvadi, Segan, Tuttle, et al., Mol. Pharmacol.  2008 Feb. 5  Epub ahead of print, PMID# 18252805.

Curcumin Induces Chemo/Radio-Sensitization in Ovarian Cells and Curcumin Nanoparticles Inhibit Ovarian Cancer Cell Growth, Yallapu, Maher, Sundram, et al., J. Ovar. Res. 2010; 3: 11.

Berberine Inhibits Acute Radiation Intestinal Syndrome in Human with Abdomen Radiotherapy, Li, Wang, Hu, et al., Med. Oncol. 2010; 27 (3): 919-925.

Randomized Phase II Trial of High-dose Melatonin and Radiation Therapy for RPA Class 2 Patients with Brain Metastases (RTOG 0119),   Berk, Berkey, Rich et al., Int. J. Radiat. Oncol. Biol. Phys. 2007 Jul 1;68(3):852-7. Epub 2007 Apr 6.

Oral Glutamine to Alleviate Radiation-Induced Oral Mucositis: A Pilot Randomized Trial, Huang, Leung, Wang, et al., Int. J. Radiat. Oncol. Biol. Phys. 2000; 46 (3): 535–539.

Prevention of Chemotherapy and Radiation Toxicity with Glutamine, Savarese, Savy, Vahdat, et al., Cancer Treat. Rev.  2003: 29 (6): 501-513.
Protective Effects of Berberine on Radiation-Induced Lung Injury via Intercellular Adhesion Molecular-1 and Transforming Growth Factor-beta-1 in Patients with Lung Cancer, Liu, Yu, Zhang, et al.,  Eur. J. Cancer 2008; 44 (16): 2425-2432.  Epub 2008 Sep 11.
Interferon-Gamma Links Ultraviolet Radiation to Melanomagenesis in Mice, Zaidi, Davis, Noonan, et al., Nature 2010, DOI: 10.1038/nature09666.
Soy Isoflavones in Conjunction with Radiation Therapy in Patients with Prostate Cancer. Ahmad, Forman, Sarkar, et al. Nutr. Cancer  2010; 627: 996-1000.

STEM CELLS  &  IMMUNE CELLS
Tumour Stem Cells: Rooting Out Resistance, Rich, et al., Nat. Rev. Cancer 2006; 6 (12): 904-905. Medscape article 550020

The Paradox of Response and Survival in Cancer Therapeutics, Huff, Matsui, Smith & Jones, Blood 2006; 107: 4321-434.

Will Cancer Stem Cell Provide New Therapeutic Targets?-  Review, Behbod & Rosen, Carcinogenesis 2004;
26 (4): 703-711.

Cancer Stem cells: Are We Missing the Target? – Commentary, Jones, Matsui & Smith, J. Natl. Cancer Inst.
2004; 96 (8): 583-585.
On Mammary Stem Cells, Woodward, Chen, Behbod & Rosen, J. Cell Sci. 2005; 118: 3585-3594.
Cancer Stem Cells - Review, Jordan, Guzman & Noble, NEJM 2006; 355 (12): 1253-1261.

Bone Marrow Derived Cells & Cancer – An Opportunity for Improved Therapy,  Houghton, Nat. Clin. Pract. Oncol.  2007; 4 (1): 2-3.  Medscape article 551187

The Lymphovascular Embolus of Inflammatory Breast Cancer Expresses a Stem Cell-like Phenotype, Xiao, Ye, Yearsley, et al., Amer. J. Pathol. 2008; 173 (2): 561-574.

Insights into Breast Cancer Heterogenicity – Stem Cells, Skinner, Nat. Rev. Cancer 2010; 10 (3): 163.

Leukaemia Stem Cells & the Evolution of Cancer Stem Cell Research, Huntley & Gilliand, Nat. Rev. Cancer  2005; 5: 311-321.

Human Pancreatic Cancer Stem Cells Identified, Simenone, et al., Cancer Res. 2007  Medscape article 551581

Brain Tumor Cells Lurk in Perivascular Niches, Gilbertson, Cancer Cell  2007; 11: 3-5, 69-82.   Medscape article 551315.

Bone Morphogenetic Proteins Inhibit the Tumorigenic Potential of Human Brain Tumor-initiating Cells, Piccirillo & Vescovi, Nature 2006; 444: 761-765.   

Brain Tumour Stem Cells, Vescovi, Galli, and Reynolds, Nat. Rev. Cancer 2006; 6 (1): 425-436.

Targeting Breast Stem Cells with the Cancer Preventive Compounds Curcumin and Piperine, Kakarala, Brenner,    Korkaya, et al., Breast  Cancer Res. Treat.  2009 [Epub ahead of print]  PMID: 19898931

Relation of Tumor Associated Macrophages and Mast Cells of Tumor Interstitum and Angiogenesis in Non-small Cell Lung Cancer, Zou & Hu, Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007; 32 (6):1037-1041.

Association of Macrophages, Mast Cells and Eosinophil Leukocytes with Angiogenesis and Tumor Stage in Non-small Cell Lung Carcinomas (NSCLC), Tataroğlu, Kargi, Ozka, et al., Lung Cancer  2004; 43 (1): 47-54.
Inflammatory Cell Infiltration of Tumors: Jekyll or Hyde, Talmadge, Donkor & Scholar, Cancer Metastasis Rev. 2007; 26 (3-4): 373-400.
Human Macrophages Promote the Motility and Invasiveness of Osteopontin-knockdown Tumor Cells, Cheng, Huo, Kuang, et al., Cancer Res. 2007; 67( 11): 5141-5147.

Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion,  Clark, Hingorani , Mick, et al.,   Cancer Res. 2007;67 (19): 9518-9527.